Meprobamate
A to Z Drug Facts
Meprobamate |
(meh-pro-BAM-ate) |
Equanil, Meprospan, Miltown, ApoMeprobamate, Meditrara, Novo-Mepro |
Class: Antianxiety |
Action Produces CNS depressant action at multiple sites, including thalamic and limbic systems.
Indications Management of anxiety.
Contraindications Hypersensitivity to meprobamate or related compounds, such as carisoprodol; cute intermittent porphyria.
ADULTS: TABLETS: PO 1.21.6 g/day in 34 divided doses. Sustained release capsules: PO 400800 mg bid. CHILDREN 612 YR: TABLETS: PO 100200 mg bid to tid. SUSTAINED RELEASE CAPSULES: PO 200 mg bid.
Alcohol, CNS depressants: May produce additive CNS depression.
Lab Test Interferences None well documented.
CV: Palpitations; tachycardia; syncope; hypertension; hypotensive crisis; arrhythmias. CNS: Drowsiness; ataxia; euphoria; slurred speech; dizziness; headache; paradoxical excitement. GI: Nausea; vomiting; diarrhea. HEMA: Leukopenia; thrombocytopenia; agranulocytosis; aplastic anemia. OTHER: Hypersensitivity (eg, rash, itching, fever, chills, edema, bronchospasm, anaphylaxis, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, bullous dermatitis); exacerbation of porphyria symptoms.
Pregnancy: Category D. Use with extreme caution, if at all. Lactation: Excreted in breast milk. Children: Do not give to children < 6 yr; safety and efficacy not established. Do not give 600 mg tablet to children. Dependence: Physical and psychological dependence and abuse may occur. Avoid prolonged use, especially in patients prone to addiction. Abrupt discontinuation after prolonged or excessive use may precipitate withdrawal symptoms with risk of seizures. Elderly or debilitated patients: Use lowest effective dose to avoid oversedation. Hypersensitivity: Usually seen between first and fourth dose in patients without previous exposure. Renal or hepatic impairment: Use drug with caution to avoid accumulation.
PATIENT CARE CONSIDERATIONS |
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Copyright © 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts